The Panthers led 19-9 after one, before outscoring the Rebels 32-13 in the second.
Drey topped 30 for the second straight game as he put up a season-high 33 points on 16-of-25 shooting. He added 12 rebounds, three assists, six steals and four blocks. Lenhart knocked down 11-of-19 for 28 points, eight rebounds, eight assists and four steals. Dillan Smith had seven points, 10 assists and three steals, and Joe Sandhoff had three points and five boards.
The Panthers knocked down 33-of-60 from t he floor and 8-of-12 at the line.
St. Mary's also bested Remsen St. Mary's on Monday, 72-29. Drey posted 31 points and 14 rebounds in that contest, and Lenhart put up 20 points and six assists.
The loss was the sixth straight for the Rebels, who drop to 4-13 with the defeat. They did more than double up their scoring after a 20-point outing against the Panthers earlier in the season. Austin Glawe hit 8-of-17 to put up 19 points and seven rebounds. Tim Saunders had seven points and four boards before leaving with an injury, Christian Sylvester scored six, and Chris Ripke had five points and four rebounds.
"I thought we did a fairly nice job of handling the pressure St. Mary's throws at you," said Sioux Central head coach Stephen Tjaden. "Unfortunately, we missed some opportunities at the free throw line in the first half and got ourselves in some foul trouble. We did a lot of good things. Hats off to St. Mary's. They showed why they are one of the top teams in the state."
The Rebels host South O'Brien Thursday and close the season next week with games at home against Newell-Fonda, Tuesday, and at Pocahontas Area on Thursday.
The Panthers host Laurens-Marathon on Friday night before they wrap up on the road against Alta-Aurelia next Tuesday and East Sac County next Friday.
The district pairings were released on Wednesday, and the Panthers earned themselves a first round bye. They will host a Valentine's Day matchup against either Glidden-Ralston or Paton-Churdan. Laurens-Marathon and Alta-Aurelia square off opposite. The bottom half of the bracket pits Newell-Fonda against the winner of Prairie Valley and Southeast Webster, with Pocahontas Area and West Bend-Mallard. In Class 2A, the Rebels drew Emmetsburg on their home court for their opener.