Luke Lenhart poured in 31 on the night, Kennedy Drey put up 26 and Joe Sandhoff notched 14 as the Panthers pushed their unbeaten record to 11-0 on the season.
"This is the first full game we've played all season," said St. Mary's head coach Brad Wilkening. "We've been good at times. We've had stretches. It we had a bad stretch in this one, it wasn't longer than 30 seconds. "Dillan did a great job playing on (Reed) Tellinghuisen. We did a great job of helping. Our zone looked good. I'm really proud of the kids."
St. Mary's raced out to a 9-0 lead as East Sac had no answer for the Panther full-court press. They would build a 26-6 lead after one, which they widened to 49-22 by halftime.
"We were getting turnovers in the press," said Wilkening. "We were able to jump out and get the lead and never looked back."
A Lenhart three late in the third pushed it to 64-28, starting the continuous clock for the remainder of the night.
Tellinghuisen entered the game averaging a conference-leading 24 points per game, but he would finish with just 15 on the night. Tyler Jacobson and Michael Halbur added five points apiece as the Raiders dropped to 8-4 on the season.
The win was also a positive start to the Panthers' toughest stretch of games in the regular season with four more to in a row against teams with eight wins or more.
The Panthers picked up another lopsided win Thursday night, overcoming what was a close first half in an 88-52 win over Granville Spalding.
Drey totaled 28 points and 12 rebounds in that game, Lenhart had 25 points, six rebounds, six assists and seven steals, and Sandhoff had 18 points and eight boards. Dillan Smith dished out seven assists to go with three points and three rebounds. Josh Scuffham added four rebounds and Eric Broich two points.
The Panthers remain at home Tuesday to welcome in a Newell-Fonda team that took them to overtime back on November 30th.