Class 1A No. 8-ranked Newell-Fonda handed St. Mary's a 97-34 loss Friday at the Panther Pit, with Katelyn Laursen leading the way with a game-high 19 points.
The Mustangs improved to 10-1 overall and 8-0 in the Northwest Conference, while St. Mary's dipped to 0-11, 0-8.
N-F led 27-11, 55-17 and 75-23 after the first three periods respectively.
Jen Dimig paced St. Mary's with 13 points.
Anyssa Lenhart added seven, Cayla Egesdal, Rylee Paterson and Melanie Snyder all had four, and Emily Mohr chipped in two.
Paterson, who has a foot injury, was operating at about 30 percent, Panthers coach Herb Besaw said.
"We did pretty good the first quarter and a half, then just got tired," he said. "But we're getting there. We were a lot better than the first time we played them (a 99-20 loss). We're starting to run the offense a little bit. We're doing better against the press, being a little more patient against it.
"They're all starting to score a little more; earlier we only had two girls score. Now the points are distributed a little bit."
Lauren Devereaux added 11 points for the Mustangs, while Becky Seivert had 10, Ellen Gruntorad and Susan Kies both scored nine, and Karina Overgaard notched eight.
"This was a good way for us to start off the second half of our season. We started a little slow, but our girls did a great job of playing with energy and enthusiasm," N-F coach Dick Jungers said. "They gave great effort. I am proud of how unselfish this group of kids are and how they always make the extra pass to an open teammate.
"That is a little thing that makes this team better."